The Determination of serum Adropın level according to concentration levels of HbA1c in patients wıth Type 2 Diabetes Mellitus

Purpose: Adropin is discovered in recent years and it has been reported to be associated with glucose and lipid metabolism . Our aim is to determine the relationship between blood serum adropin levels according to blood glycosylated hemoglobin (HbA1c) concentration values between the patient groups diagnosed with Type 2 Diabetes Mellitus and the control group. Methods: A total of 60 Type 2 DM, 20 prediabetes for observation were recruited from Endocrinology clinic of Fırat University Hospital. In addition, 20 healthy subjects were recruited for comparison as the normal control group. A total of 60 DM patients were divided into 3 equal groups according to HbA1c levels as 20 patients with HbA1c levels greater than 9 %, 20 between 7-9 %, 20 less than 7 %. In addition to routine blood tests, adropin levels were measured by ELISA method. Results: Patients with DM had lower serum adropin levels when compared with the controls (4,12±1,23 ng/mlversus 4,84±1,41 ng/ml, p 9% was lower in comparison with control group (3,23±1,14 ng/ml versus 4,84±1,41ng/ml, p < 0.001). In diabetic patients we determined negative correlation between HbA1c and adropin levels (r=-0.377, p < 0.05). Conclusion: In this study, we found that adropin levels were reduced with increasing levels of HbA1c. It appears that chronic hyperglycemia or poor blood sugar regulation lowers adropin levels. In the future, on this subject further studies are needed.