Possibilities of local therapy of mixed nonspecific bacterial-fungal vaginal infections

Introduction. The consequences of these mixed nonspecific vaginitis are manifested in the aggravation of the course of the disease, the complexity of diagnosis and the choice of therapy. Aim. Evaluation of the clinical and microbiological efficacy of a complex drug including clindamycin and butoconazole in local therapy of patients with mixed forms of nonspecific bacterial-fungal vaginal infections. Material and methods. 126 patients with a confirmed diagnosis of “mixed nonspecific bacterial-fungal vulvovaginitis”. The proposed therapy is a vaginal cream containing clindamycin phosphate and butoconazole nitrate (1 dose (5.0 g) for 6 days). Clinical and microbiological efficacy was assessed at 14 days (22 ± 3 days from the start of therapy – stage V2), 1 month (40 ± 3 days from the start of therapy – stage V3) and 3 months (100 ± 3 days from the start of therapy – stage V4) after the end of therapy. Results. Topical use of a drug containing an antibiotic (clindamycin phosphate) and an antimycotic (butoconazole nitrate) contributes to the leveling of clinical symptoms in the form of itching and dyspareunia, respectively, in 94.45% and 92.9%, pathological whites in 91.3% of women, normalization of the pH of vaginal secretions in 92.1% of patients. Microbiological efficacy at the end of the follow-up period was 88.1% (Hay/Ison Grade 1 and 2), 90.5% (Donders Grade <3) and 86.5% PCR. Conclusion. Clinical and microbiological evaluation of the use of containing an antibiotic (clindamycin phosphate) and an antimycotic (butoconazole nitrate) as a seven-day therapy, having a wide range of antibacterial and antimycotic activity with good tolerability, has shown high efficacy in the treatment of patients diagnosed with mixed nonspecific bacterial-fungal vulvovaginitis, which allows it to be recommended for the treatment of women with This nosology, and also offers a safe and effective option for empirical therapy of various vaginal infections.