Intrahepatic Microbial Heterogeneity in Multifocal Hepatocellular Carcinoma and Its Association with Host Genomic and Transcriptomic Alterations
We reveal intraindividual heterogeneous microbial communities among nodules from patients with multifocal HCC. IM-HCC-enriched bacteria promote tumor growth and influence the tumor microenvironment of HCC. Our work highlights the necessity of considering bacterial heterogeneity as biomarkers and targets for multifocal HCC therapeutic intervention. See related commentary by Dzutsev and Trinchieri, p. 1540.
Authors
- Weikang Chen (ORCID: https://orcid.org/0009-0007-8992-6190)
- Qianying Zhou (ORCID: https://orcid.org/0009-0001-7486-0295)
- Chi Chun Wong (ORCID: https://orcid.org/0000-0003-1362-3541)
- Ying Zhang (ORCID: https://orcid.org/0000-0002-5545-5294)
- Ming Kuang (ORCID: https://orcid.org/0000-0002-7397-5779)
- Xin Liu (ORCID: https://orcid.org/0000-0002-7529-3149)
- Pingmei Huang (ORCID: https://orcid.org/0000-0002-4893-8159)
- Kaili Fu
- Lixia Xu (ORCID: https://orcid.org/0000-0002-1818-6267)
- Na Wang (ORCID: https://orcid.org/0009-0005-7481-5004)
- Jun Qing Yu (ORCID: https://orcid.org/0000-0001-5008-2153)
- Xueliang Wang (ORCID: https://orcid.org/0000-0001-5406-2109)
- Weixin Liu (ORCID: https://orcid.org/0000-0002-1650-0371)
- Wenxuan Xie
- Shu Xu (ORCID: https://orcid.org/0000-0001-6391-2603)
- Yinghong Lu
- Yongxin Zhang (ORCID: https://orcid.org/0000-0001-7558-5136)
- Haojie Bai
Institutions
- Sun Yat-sen University (CN)
- Chinese University of Hong Kong (HK)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-04-27
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-1259
- Citations
- 14
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 14.64