Ways to Enhance the Diagnosis of Pulmonary Sarcoidosis (Literature Review)

The article analyzes 50 publications devoted to diagnostic approaches to detection of sarcoidosis. It highlights that currently diagnosis of this disease is not standardized and thus errors are highly possible to occur. Improved approaches address all aspects of diagnosis, from the distinction of highly specific clinical and radiologic signs of the disease to the choice of lung biopsy method. The use of sarcoidosis biomarkers such as angiotensin-converting enzyme, chitotriosidase, and serum amyloid A is most promising. The possibility of their combination and association with clinical signs of the disease are being studied, and to discover new biomarkers, full-genome studies are being in progress.