Therapy for Prevention and Relief of Hepatotoxic Reactions in Patients with Drug Resistant Tuberculosis

The objective : prevention and relief of hepatotoxic reactions to antituberculosis drugs in patients with infiltrative destructive pulmonary tuberculosis with multiple, pre-extensive and extensive drug resistance. Subjects and Methods . Clinical and laboratory data of 160 patients receiving antituberculosis drugs and additionally morpholinium-methyl-triazolyl-thioacetate (Thiotriazolin) (TTZ Group) or Phosphogliv (Comparison Group (CG)) were comparatively analyzed. Results . After 4 months, TTZ Group showed a decrease in frequency of toxic reactions to antituberculosis therapy, suppression of cytolysis and cholestasis syndrome as evidenced by decreased levels of ALT and AST enzymes, alkaline phosphatase, normalization of bilirubin levels and its fractions, and improved liver protein-synthetic function. In TTZ Group, normalization of the antioxidant defense system and free radical oxidation (FRO) was achieved, while in the comparison group, FRO rates did not show positive changes. Patients in TTZ Group showed more pronounced resorption of infiltration, healing of destruction sites, decrease in the frequency of bacterial excretion 4 months after the start of treatment versus Comparison Group.