Experimental Evaluation of the Effect of Coenzyme Q10 on Toxicity of a Combination of Antituberculosis Drugs

The objective : to study toxicity modifying effects of Coenzyme Q10 in toxic reactions caused by a combination of antituberculosis drugs in the rat experiment. Subjects and Methods . 30 non-linear female rats weighing 230-250 g, divided into 3 groups were used in the experiment. Control Group (CG) received 1% starch gel. Experimental Group 1 (EG1) received a combination of 5 antituberculosis drugs: Mxf + Bdq + Lzd + Cs + Z, Experimental Group 2 (EG2) received the same antituberculosis drugs, and additionally Coenzyme Q10 as the drug product of Qudesan, 30 min before the combination of antituberculosis drugs. Doses of antituberculosis drugs and Coenzyme Q10 were equivalent to human therapeutic doses used in the clinic. The manifestation of toxic reactions in rats was evaluated by body weight changes, clinical and biochemical blood parameters, changes in ECG and behavioral reactions in the open field test, and morphological changes in organs and tissues. Results . Coenzyme Q10 showed the ability to modify cardio-, hepato-, hematoto- and nephrotoxicity induced by antituberculosis drugs at functional and morphologic levels. It was impossible to assess the neuroprotective effect of Coenzyme Q10 in the dose used due to weakly expressed changes in behavioral reactions in rats after the combination of antituberculosis drugs compared to Control Group.