Polycyclic Polyprenylated Acylphloroglucinols from Hypericum himalaicum
Six previously undescribed polycyclic polyprenylated acylphloroglucinols (PPAPs) with a vicinal diol moiety (1: -6: ) were isolated from the whole plant of <i>Hypericum himalaicum</i>. Their structures were established through a comprehensive analysis of HRMS and 1D and 2D NMR data, while the absolute configurations were determined using the Mo<sub>2</sub>(OAc)<sub>4</sub>-induced circular dichroism (ICD), ECD, and NMR calculations. Compound 1: attenuated the secretion of NO, TNF-<i>α</i>, and IL-6, downregulated the protein expression of COX-2 and iNOS, and inhibited the release of ROS in LPS-induced RAW264.7 macrophages. Further investigation revealed that the anti-inflammatory effects may be attributed to the inhibition of the NF-<i>κ</i>B and NLRP3 signaling pathways.
Authors
- Yu‐Cheng Gu (ORCID: https://orcid.org/0000-0002-6400-6167)
- Da‐Le Guo (ORCID: https://orcid.org/0000-0003-3219-7066)
- Fan Wu (ORCID: https://orcid.org/0000-0002-7275-7649)
- Guang‐Hui Liu (ORCID: https://orcid.org/0000-0001-9289-8177)
- Yan Zhou (ORCID: https://orcid.org/0000-0002-3213-8229)
- Hong-Bing Sun (ORCID: https://orcid.org/0000-0002-3115-7145)
- Zhuo-Lin Jin
- Xue-Yan Huo
Institutions
- Chinese Academy of Sciences (CN)
- Syngenta (United Kingdom) (GB)
- Chengdu Organic Chemicals (China) (CN)
- Chengdu Institute of Biology (CN)
- University of Chinese Academy of Sciences (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Planta Medica
- Published
- 2025-04-28
- DOI
- https://doi.org/10.1055/a-2596-3029
- Primary Topic
- Natural Compound Pharmacology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Key Research and Development Program of Sichuan Province