Auto Immune Glial Fibrillary Acidic Protein Astrocytopathy Coexistent with Positivity for Anti-NH<sub>2</sub>-terminal of α-enolase Antibodies
A 46-year-old woman presented with acute disturbance of consciousness, ataxia, and urinary retention. Although Hashimoto's encephalopathy was initially suspected due to the detection of serum anti-NH<sub>2</sub>-terminal α-enolase (NAE) antibodies, glial fibrillary acidic protein (GFAP)-astrocytopathy was also considered probable due to urinary retention. An additional examination revealed positive results for both anti-GFAP and anti-NAE antibodies. This case highlights the importance of considering antibodies to be examined based on clinical features, even in the presence of antibodies.
Authors
- Tadashi Terasaki (ORCID: https://orcid.org/0000-0001-5379-5933)
- Satoshi Namitome (ORCID: https://orcid.org/0009-0001-8321-9109)
- Mitsuharu Ueda (ORCID: https://orcid.org/0000-0002-6814-0582)
- Makoto Nakajima (ORCID: https://orcid.org/0000-0003-3547-1307)
- Yasuyuki Hara
- J. Matsuo
Institutions
- Japanese Red Cross Kumamoto Hospital (JP)
- Kumamoto University (JP)
Publication Details
- Journal
- Internal Medicine
- Published
- 2025-04-28
- DOI
- https://doi.org/10.2169/internalmedicine.5528-25
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00