Volumetric and Compressibility Studies of Antimycobacterial Drug in Aqueous and Aqueous <scp>d</scp>-Glucose Solutions at Various Temperatures

The experimental density (ρ) and speed of sound (c) data for the antimycobacterial drug ethambutol dihydrochloride (ETB·2HCl) in aqueous solution and aqueous d-glucose solutions containing fixed concentrations (0.06 and 0.1 mol·kg–1) across the concentration range 0.01 to 0.15 mol·kg–1 at different temperatures (293.15, 298.15, 303.15, 308.15, and 313.15 K) are reported. The experimental ρ and c data were used to compute different volumetric and compressibility parameters, including the apparent molar volume of solute (VΦ), limiting apparent molar volume of solute (VΦ0), limiting apparent molar expansivity of solute (EΦ0), thermal expansion coefficient (α), isentropic compressibility of solution (κs), apparent molar isentropic compression of solute (Ks,Φ), limiting apparent molar isentropic compression of solute (Ks,Φ0), and hydration number (nk). Additionally, the partial molar volume of transfer (ΔtrVΦ0) and partial molar isentropic compression of transfer (ΔtrKΦ0) parameters for the considered drug from water to aqueous d-glucose solutions were estimated. The results are interpreted in terms of molecular interactions in the studied systems.