Tinosporine alleviates collagen-induced arthritis in rats via modulating the gut microbiota-metabolome-immunity axis
TIN inhibited the inflammatory response of CIA rats by regulating the gut microbiome-metabolome-immunity axis, reversed the abnormalities of intestinal flora and differential metabolites, and maintained the integrity of the intestinal barrier.
Authors
- Wenyu Yang (ORCID: https://orcid.org/0000-0001-5885-3450)
- Huijuan Xu (ORCID: https://orcid.org/0000-0002-1858-1822)
- Yafan Li
- Chuan Liu (ORCID: https://orcid.org/0000-0002-9719-1506)
- Peng Wang (ORCID: https://orcid.org/0000-0001-8695-6721)
- Ling Li (ORCID: https://orcid.org/0000-0002-0087-3034)
- Ya Tu (ORCID: https://orcid.org/0000-0001-8944-4174)
- Ping Wang (ORCID: https://orcid.org/0000-0001-8049-2495)
- X. Yi (ORCID: https://orcid.org/0000-0001-8603-5893)
Institutions
- Xihua University (CN)
- Chinese Academy of Agricultural Engineering (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-04-28
- DOI
- https://doi.org/10.1016/j.intimp.2025.114752
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81