Impact of Brain Frailty on Clinical Presentation and Neurologic Recovery in Acute Ischemic Stroke Patients Undergoing Thrombectomy

This study highlights the association of brain frailty with the clinical presentation and recovery trajectory of patients with AIS undergoing EVT. Specifically, cortical atrophy was independently associated with baseline stroke severity, and the total burden of brain frailty was independently associated with NIHSS recovery trajectories. The results emphasize the importance of considering brain frailty in acute stroke management and prognostication.

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Journal
Neurology
Published
2025-04-28
DOI
https://doi.org/10.1212/wnl.0000000000213619
Citations
6
Primary Topic
Acute Ischemic Stroke Management
Type
article
Field-Weighted Citation Impact
8.13
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article

Impact of Brain Frailty on Clinical Presentation and Neurologic Recovery in Acute Ischemic Stroke Patients Undergoing Thrombectomy

Alex Brehm, M. Thorén, Diane Goodman, Faysal Benali et al.
6 citations
Neurology
Acute Ischemic Stroke Management
8.13
article

Impact of Brain Frailty on Clinical Presentation and Neurologic Recovery in Acute Ischemic Stroke Patients Undergoing Thrombectomy

Alex Brehm, M. Thorén, Diane Goodman, Faysal Benali, Steven Peters, G Paolucci, Ginette Wortmann, Sharleen Maley, Charles S. Haw, Stephen English, Dan Gzesh, Sebastián Fridman, Mar Lloret, Niaz Ahmed, Richard Farb, Michael J. Waters, Christina C. Watkins, Angela Sauer, Cynthia Oliva, Brian Katz, Sarah Coveney, Ticey N. Massengale, Hee-Kwon Park, Charith Cooray, Erin Dyer, Darcy Blackstock, Ivan Wiggam, Houman Khosravani, Carmen Parra-Fariñas, Lissa Peeling, Pawel Kostyrko, Ji Hoe Heo, Young Dae Kim, Pascale Lavoie, Jin Kyo Choi, Sujeong Jeon, Lisa Baxendell, Suzanne Tauro, Janice Anne Y. Chua, Thien J Huynh, Tudor G. Jovin, Ericka Teleg, Ewgenia Barow, Piyush Ojha, Jose Danilo Bengzon Diestro, Gita Sobhi, Cheryl Jaigobin, Marjorie Delucia, Maxim Bester, Paige Fairall, Neeraj S. Naval, Ann Bedenk, Nils Petersen, Zeinab Daham, Melina Lorraine Ferreira, Roy Drew, Scott Dellorso, Christoph Stretz, Jai Shankar, Aviraj S. Deshmukh, Donald Lee, Bernardo Liberato, Aditya Bharatha, Philip Teal, John Thornton, Annette Haché, Lauren Hachmann Sansing, Luciano Alberto Sposato, Shelagh B. Coutts, Ajit S Puri, Lee Dickerson, Joanna D. Schaafsma, Emily J. Gilmore, Anne Cayley, Alexandra Prakapenia, Joachim Fladt, Linda Andersen, Céline Odier, L Zimmel, Srikant Rangaraju, Tiago Moreira, Neil D. Maluste, Mark E. Talley, Katyucia DeMacedo Rodrigues, Maher Saqqur, Eric Edward Smith, Moonkyung Choi, Scott D. Caganap, Jennifer L. Mandzia, Hailey Orgass, Helen Shen, Debabrata Chakraborty, Lindsay Waxman, Brian Drake, Nicholas Osteraas, Caroline Deegan, Julia Müller, Fana Alemseged, Genoveva Maclean, Marie‐Christine Camden, Rebecca E. Brierley, Alisia Southwell, Sanchea Wasyliw, Michael Tymianski, Nawaf Yassi, Richard Dowling, George Α. Lopez, Bernard Yan, Gregory Walker, Jan Liman, Ralph Weber, Kelsea Toseki Haibach, Karthikeyan Arcot, Andrew M. Demchuk, Emma Martin, Lilian Urroz, Henry Zhao, Haseeb Rahman, Judlène Jolteus, Grégory Jacquin, Kaitlyn Lopes, Nabeel Muzaffar Syed, Becky Holtz, Maria Cortes, Patrick Salvaris, Stefanie Meister, Benjamin P. George, Brian H Buck, Kaile Neuschatz, Cameron G. McDougall, Martín del Campo, Patricia Bussinger, Simon Winzer, John McCabe, Mohamad Chmayssani, Ashley L. DePalmo, Karina Murray, Howard Lesiuk, Kishan Patel, Jean Raymond, Grant Stotts, Michael V. Mazya, Steven DiCrescento, Julie Lynch, Frank L. Silver, Charles Wira, Jo-Lyn Ng, Michael Schönfeld, Joung‐Ho Rha, Robert Ashforth, Bastian Cheng, Ramiro Larrazabal, Timothy John Kleinig, Treasure A. Joyce, Kathrin Haase, Meagan Schultz, Omran Kaskar, Katie Ponting, Ariane Mackey, Marlena Schnieder, Maneesha Kamra, Aravind Ganesh, Nata DeVole, Laurie Williams, Nicholar Maraj, Jason Faggard, Sarah Power, Nicole C. Demir, Sara Jasak, Debbie MacDonald, Diana Zúñiga, Kuan H. Ng, Margret Schwarz, Mark Angle, Catrice M. Nakamura, Julian Spears, Amy Yu, Patricia Fearon, Gwynedd E. Pickett, Brian Thomas Jankowitz, Zuzana Barbret, Philippe Couillard, Robert Vandorpe, Katherine M. Groezinger, Aaron Loochtan, Donald Frei, Jeremy Liff, Saad Alqatani, Belinda Amato-Marziali, Nancy Newcommon, Kunakorn Atchaneeyasakul, Iris Lettow, Geoffrey Alan Donnan, Tanaporn Jaroenngarmsamer, Lars‐Peder Pallesen, Wieslaw Oczkowski, Caspar Brekenfeld, Rachel Beekman, Amy McDonald, Darshan Doshi, Marcelo Rocha, Karen Misquitta, Märit Jensen, Michael Chow, Ronit Agid, Shelly Bohn, Hyo Suk Nam, Jay Z. Yao, Justin Létourneau, Nadia Jadil, Sharanpal Mann, Kyungsun Jeong, Kirsten Jaramillo, Pyoung Jeon, María Bres Bullrich, Ailbhe Cullen, Eric A. Sauvageau, Roland C. Veltkamp, Lisa M. Kodis, Ashkan Shoamanesh, Jeong‐Ho Hong, Liam Durcan, Cheyanne Vandervelde, Roisin Walsh, Erica Scher, Jessica Tsoleridis, Brad Klein, Alexander V. Khaw, Mohamed Badawy, Judy Guzy, Sachin Pandey, Brian Dewar, Prabhu D. Emmady, Laura Gioia, Vivek Rai, Michael C. Stauder, David Turkel‐Parrella, Mathew Hannouche, Ahmed M. Alshanbari, Manas Sharma, Donatella Tampieri, Geneviève Milot, Ashutosh P. Jadhav, Rosalin Chiu, Tiffany C. Talley, Mitch Hargis, Wynne Abdon, Michael Marnane, Monica Gossett, Duandelyn C. Wilson, Lindsay Lambourn, Salma Khalil, Oh Young Bang, Dar Dowlatshahi, Rebecca Scroop, Robert Darflinger, Reema Butt, Michael Ke, Shannon Doppelheuer, Nirav Bhatt, Peter A. Ringleb, Nick Telischak, Sarah Cuddy, Alhamza R Al‐Bayati, Renee Ovando, Talat Alvi, Cathy Patterson, Merritt Brown, Martha Marko, Lanai Lewis, Anna Luisa Kühn, Daniela Iancu, Andrij Abramyuk, Sibi Thirunavukkarasu, Anna Steinberg, Zuolu Liu, Sean Murphy, Aaron Garner, Gustav Neitz, Hayrapet Kalashyan, Melfort Boulton, Cindy Simpson, Oscar Benavente, Tara C. Abbott, William J. Maloney, Daniel P. O. Kaiser, Ashfaq M Shuaib, Håkan Almqvist, Gary Hunter, Karl Boyle, Stephen J. Monteith, Tim Stewart, Chlin R. Tennyson-Yemm, Adrienne Weeks, Patricia Feineigle, Julia Fernandess, Milani Deb‐Chatterji, William Morrish, Jean‐Luc Gariépy, Benjamin J. Ludwig, Guido J. Falcone, Erin L. Cole, Jessica Redford, Michael Mayich, Ileana Grunberg, Brad K. Fasbinder, Paul Burns, Jacquelyn Charlton, Fabio Settecase, Derek J. Schemmel, Jason S. Day, Timo Krings, Peter K. Stys, M Howk, Ann-Marie Liddy, Timo Siepmann, Debbie Summers, Michel Christopher Frank Shamy, Lori Piquette, Åke Holmberg, John Khoury, Alain Weill, Cian O′Kelly, Anna Balabanski, Marta Wallocha, Robert P. Brennan, Christina Roels, Mark S. Umekubo, Ali Zohair Nomani, Bradley A. Gross, Kristiana Salmon, Firas Kaddouh, Colin T. McDonald, Cari Jahraus, P. Alan Barber, Adrian M Burgos, Brett Graham, Sean P. Barrett, Abdulaziz Sulaiman Alsultan, Jaydevsinh N. Dolia, Maryam Zulfiqar, Joonsang Yoo, Mahesh Jayaraman, Harrison Pearl, Danoushka Tememe, Nathan Gaines, Steven Bush, Go-Eun Jun, Adam S. Jasne, Jens Fiehler, Rick Swartz, Danielle de Sá Boasquevisque, W Holloway, M Brown, Nishita Singh, Anitha Jambula, Simerpreet Bal, Karen Bell, Supriya Save, Sleiman El-Jamal, Benjamin Atchie, Thomas R. Marotta, Enda Kerr, Ankur Wadhwa, David Williams, Cathy Van Every, Josephine Baldwin, Perdita Beck, Robin G. Walters, Sidney Starkman, Gregory Filipowski, Friederike Koch, Fouzi Bala, Yan Deschaintre, C. LEGAULT, Alex A. Edinger, Joey English, Aimen Moussaddy, Stephen Phillips, Ondřej Volný, Yangmei Li, Felix Ng, Suresh Subramanian, Billy Gao, Kanjana Perera, Ruba Kiwan, Gustavo Saposnik, Aoife Laffan, Mays Shawawrah, Sinéad McElroy, Daniel F. Kelly, Jessica Choe, Jennifer H. Czerniak, Atlantic D’Souza, Michael Frankel, Susan V. MacMillan, Sung‐Il Sohn, Leah Craft, Alana M. Flexman, Ryan McTaggart, Peter J. Kelly, Jennifer Frontera, Jeanne Teitelbaum, Sumiti Nayar, Krista A. Cope, Peter Mitchell, René Chapot, Cameron Williams, Michael E. Kelly, Ekin Celik, Nancy Ebreo, Kiva Schindler, Kavit Shah, Tijil Agarwal, Thalia Shoshana Field, Karla J. Ryckborst, Susila Patel, Suzanne C. Crandall, Amin Aghaebrahim, Susan M. Foley, Jong‐Won Chung, Victor X. D. Yang, Sharon Kiszczak, Graham Smyth, Josh Ross, Ravinder Singh, Axel Rohr, Christina Sjöstrand, Stephen van Gaal, Manraj K. S. Heran, Brett Donegan, A. Laine Green, Eckhard Schlemm, Andrew Lockey, Sohyeon Kim, Samuel Yip, David C. Weisman, Brendan Eby, Dylan Blacquière, Scott A. Williams, Bruce C.V. Campbell, Geralt Roberts, Alexandre Yves Poppe, Daniel Roy, Boris Keselman, Zachary A. King, Amir Golsari, Luciana Catanese, Sonny Kupniewski, Raul G. Nogueira, Christian Stapf, In Gun Hwang, Einar E. Eriksson, Kaustubh Limaye, Woo‐Seok Ha, Trevor Kotylak, Grant Linnell, Sara Pilgram‐Pastor, Herbert A. Manosalva Alzate, Paul Stracke, Jackson Harvey, Sabrina Walker, David Tong, Leanne K. Casaubon, Keon Ha Kim, Jeffrey Farkas, Lauren Pesavento, Annika Berglund, Cynthia L. Kenmuir, Diogo C Haussen, Volker Maus, Kandan Kulandaivel, Kenneth Butcher, Annika Reinke, Mayank Goyal, Reshma Narula, Nobl Barazangi, Ethan DukSoo Han, Simon Nagel, Joseph Paul, Samir Belagaje, John D. Eatman, Barb Danenbergs, Jennifer Patterson, Maria Axelsson, Hyoeun Bae, Ruchir A. Shah, Ian Rennie, Demetrios J. Sahlas, Asif Butt, Lucy Vieira, Danielle Joset, Amanda Brown, Steve Verreault, Vítor Mendes Pereira, Aiman Quateen, Judy Yip, Yolanda Gayton, Karin Nyström, Nils Wahlgren, Nicolle L. Schraeder, Arunima Kapoor, Mark William Parsons, Claire Magnussen, Hana Choe, Erin Schaad, Angela Moore, Joan Nye, Miriam Heyse, Juline Jabs, Hyungjong Park, Brian Wells, Jared S. Halpin, Karine Collard, Michelle Wright, Matthew Starr, Marie‐Ève Audet, Nicole Hollstein, Habibullah Ziayee, Ruth Kinnear, Mark I. Boulos, Colleen B. Murphy, Hannes Appelbohm, Lucas Ramírez, Ita P. Dempsey, Sibu Mundiyanapurath, Alan O’Hare, Yun Jeong Lim, Mateo Calderon, Kristian Barlinn, G Hull, Glen C. Jickling, Johannes Gerber, Berit Bäumle, Jasmeet Singh, Peter Pema, Charles Matouk, Joanna Arsenault, Muneer Eesa, Marios‐Nikos Psychogios, Jeremy Rempel, Linda Gibson‐Young, Teddy Y. Wu, Fernando Mayor Basto, Cindy W. Yoon, Yudy Llamas-Osorio, Shana Lamers, Joanna M. Snead, Eilidh Strecha, Lavenia Cagi, Min Chen, Nicole Deneault, Josrdan M. Knapman, Noran Y. Yaher, Vicki Glichrist, Jonathan Grossber, Lorretta J. Sutherly, Ria Asunsian, Illanit Spokoyny, Lindsey R. Kouhn, Elisabeth Beyrle, Richard J. Ower, Shuo Chen, Di Wang, Jun Seok Lee, Bing Chen, Chang-Hyun Kim, Bokyung Kim, Alejandro Vargas, Michael D. Hill, Rishi G. Gupta, Nicole Müller, Jae‐Joon Lee, Aaron Anderson, Laura Wilson, Yasir Saleem, David M. Jackson, Matthias H. Schmidt, Christine Wong, Nicolas Bianchi, Xiaomeng Chen, Ângela dos Santos, Dominique Fontaine, Francesco Massari, Pratit D. Patel, Wendy Smith, Patricia Gordon, John E. Jordan, Kimberly Gray, Walter Montanera, Christine Boutwell, Naveed Akhtar, Gillian Horgan, Chrstine Hawkes, Jennifer Nichols, Julia J. Hopyan, Shawna M Cutting, Cheryl E. Kelly, Stephen Lownie, Leodante da Costa, Dagmar Otto, Daniel Selchen, Julia Hoppe, Karin Olds, Markus Möhlenbruch, Ruth Whelan, Derek J. Emery, Akshal Patel, Katrina K. Barton, Darshan G. Shan, John Wong, Alim P. Mitha, Shasvat Desai, Janice E. Williams, Bradley G. Klein, Dawn M. Petrucci, Larami Mackenzie, Aleksanda Pikula, Warren Kim, William A. Conrad, Tom Jeerakathil, Gary Redekop, Gary Klein, George P. Teitelbaum, William J. Hicks, Margaret Large, Lisa R. Griffin, Allam Ibrahim, Joseph Schindler, Carol Kenney, Mizaffar Siddiqui, Eric J. Arias, Kelsey Halbert, Allison E. Arch, Nirav Vora, Kevin Wade, Stephen M. Davis, Lindsey R. Fuller, Libby Kalman, Melanie G. Miller, Sam Y. Hou, Caitlin Loomis, Osman Kozak, Margaret McFarland, Prasanna Venkatesan, Isabelle Desloges, Tom Yeo, Richard Haas, Donald Heck, Ronald F. Budzik, M. Lauren, Anna Coppola, Hardik Amin, Kevin N. Sheth, Qaisar A. Shah, Marlène Lapierre, Karen E. Adams, Beth Beauchamp, Hemasse Amiri, Juditch Jarrett, Ian A. Kaminsky, Megan A. Leary, Peter J. Mac Mahon, Brigette Holst, Jens O. Heidenreich, Katie Quinn, Sonia Lai, Amith Sitaram, Daiv Y. Hwang, Stacy Y. Brown, Laura T. Jong, Peter Flynn, Yih Lin Nien, Gordon Gubitz, Dominic Tse, Alicia M. Mattai, Dipanka Sarma, Brenda M. Knowles, Barry J. Moynihan, Catherine T. Lynch, Coleman Martin, David J. Gladstone, Latisha Sharma, Richard J. on
article en
6 citations

Abstract

This study highlights the association of brain frailty with the clinical presentation and recovery trajectory of patients with AIS undergoing EVT. Specifically, cortical atrophy was independently associated with baseline stroke severity, and the total burden of brain frailty was independently associated with NIHSS recovery trajectories. The results emphasize the importance of considering brain frailty in acute stroke management and prognostication.

NeurologyVol. 104(10)
Université de Tours (FR), University Health Network (CA), University of Alberta (CA), University of Calgary (CA), University of Pittsburgh (US), University of Basel (CH), University of Toronto (CA), Providence College (US), Mahidol University (TH), Maastricht University Medical Centre (NL), Rhode Island Hospital (US), University Hospital of Basel (CH), Centre Hospitalier Universitaire de Tours (FR), Ramathibodi Hospital (TH), Centre Hospitalier de l’Université de Montréal (CA), AZ Sint-Blasius (BE), Krembil Research Institute, University of Manitoba (CA), Libin Cardiovascular Institute of Alberta (CA)
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Acute Ischemic Stroke Management
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