Body weight-supported treadmill training reduces glial scar overgrowth in SCI rats by decreasing the reactivity of astrocytes during the subacute phase
Our study demonstrates that a sustained BWSTT intervention during the subacute phase of spinal cord injury can effectively reduce astrocyte reactivity and glial scarring overgrowth, thereby facilitating functional recovery after SCI.
Authors
- Chenyuan Zhai
- Qi Wu (ORCID: https://orcid.org/0000-0003-2034-5746)
- Tong Wang (ORCID: https://orcid.org/0000-0002-6667-6498)
- Wentao Liu (ORCID: https://orcid.org/0000-0001-8732-7927)
- Chenchen Zhu (ORCID: https://orcid.org/0009-0009-2198-150X)
- Lu Fang (ORCID: https://orcid.org/0009-0006-3274-4225)
- Yu Wang (ORCID: https://orcid.org/0000-0001-8697-2940)
- Jili Cai
- Kunmao Jiang
- Xiangzhe Li
- Zun Wang
Institutions
- Nanjing University of Chinese Medicine (CN)
- Suzhou Municipal Hospital (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- BMC Neuroscience
- Published
- 2025-04-28
- DOI
- https://doi.org/10.1186/s12868-025-00947-7
- Citations
- 1
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province