Targeting inflammasome pathway towards therapeutics of neurodegenerative diseases.

Inflammasome, an intracellular protein complex, is a crucial regulator of the innate immune response defending against harmful insults. Increasing evidence indicates that activation of inflammasome pathway in brain cells plays a significant pathological role in neurodegenerative diseases. Targeting this pathway offers a promising strategy for developing novel treatments. Here, we review the wide-ranging involvement of inflammasome activation in neurodegenerative diseases and highlight current therapeutic strategies targeting this critical pathway.