Single-cell Transcriptional Atlas of Human Hematopoiesis Reveals Genetic and Hierarchy-Based Determinants of Aberrant AML Differentiation
We present a single-cell reference atlas of human hematopoiesis and a computational tool for rapid mapping and classification of healthy and leukemic cells. Applied to AML, this has enabled single-cell analysis at the scale of hundreds of patient samples, revealing the full breadth of derailment of differentiation in AML. See related commentary by Berger and Penter, p. 280.
Authors
- Qingsong Gao (ORCID: https://orcid.org/0000-0002-9930-8499)
- Mark D. Minden (ORCID: https://orcid.org/0000-0002-9089-8816)
- Suraj Bansal (ORCID: https://orcid.org/0000-0003-4023-6635)
- Hyerin Kim
- David Chen (ORCID: https://orcid.org/0000-0003-3178-519X)
- Torsten Haferlach (ORCID: https://orcid.org/0000-0003-0196-2837)
- Sayyam Shah (ORCID: https://orcid.org/0009-0005-1064-3223)
- Charles Grenfell Mullighan (ORCID: https://orcid.org/0000-0002-1871-1850)
- James A. Kennedy (ORCID: https://orcid.org/0009-0007-2844-2256)
- Ilaria Iacobucci (ORCID: https://orcid.org/0000-0003-2008-1365)
- Andy G.X. Zeng (ORCID: https://orcid.org/0000-0002-3223-6400)
- Andrea Arruda (ORCID: https://orcid.org/0000-0003-2516-8005)
- John E. Dick (ORCID: https://orcid.org/0000-0002-9527-8317)
- Amanda Mitchell
- Gordon Wong
Institutions
- St. Jude Children's Research Hospital (US)
- Sunnybrook Health Science Centre (CA)
- University Health Network (CA)
- University of Toronto (CA)
- Princess Margaret Cancer Centre (CA)
- Munich Leukemia Laboratory (Germany) (DE)
Publication Details
- Journal
- Blood Cancer Discovery
- Published
- 2025-04-28
- DOI
- https://doi.org/10.1158/2643-3230.bcd-24-0342
- Citations
- 48
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 83.19
Funders
- Alex's Lemonade Stand Foundation for Childhood Cancer
- St. Jude Children's Research Hospital
- Princess Margaret Cancer Foundation
- American Lebanese Syrian Associated Charities
- Government of Ontario
- Canadian Cancer Society
- International Development Research Centre
- Canada Research Chairs
- Terry Fox Foundation
- University of Toronto
- Canada First Research Excellence Fund
- National Institutes of Health
- Canadian Institutes of Health Research
- National Cancer Institute