SHBG, Testosterone, and Type 2 Diabetes Risk in Middle-Aged African Women: Exploring the Effect of HIV and Menopause
We show for the first time that midlife African WH have higher SHBG and lower total and free testosterone than WOH, which corresponded to their higher β-cell function, suggesting a putative protective effect of SHBG on T2D risk in WH.
Authors
- Lisa K. Micklesfield (ORCID: https://orcid.org/0000-0002-4994-0779)
- André Pascal Kengne (ORCID: https://orcid.org/0000-0002-5183-131X)
- Karl‐Heinz Storbeck (ORCID: https://orcid.org/0000-0003-1669-6383)
- Hylton Gibson
- David M. Selva (ORCID: https://orcid.org/0000-0002-0333-5629)
- Maphoko Masemola (ORCID: https://orcid.org/0000-0002-4398-9061)
- Fredrik Karpe (ORCID: https://orcid.org/0000-0002-2751-1770)
- James Hawley (ORCID: https://orcid.org/0000-0002-9953-5544)
- Amy E. Mendham (ORCID: https://orcid.org/0000-0002-1959-6698)
- Tommy Olsson (ORCID: https://orcid.org/0000-0001-7768-1076)
- Nigel J. Crowther (ORCID: https://orcid.org/0000-0002-5766-1745)
- Clément Kufe (ORCID: https://orcid.org/0000-0001-6599-7284)
- Shane Anthony Norris (ORCID: https://orcid.org/0000-0001-7124-3788)
- Itai M. Magodoro (ORCID: https://orcid.org/0000-0002-3879-6126)
- Ikanyeng D Seipone (ORCID: https://orcid.org/0000-0003-2853-4736)
- Tinashe Chikowore (ORCID: https://orcid.org/0000-0002-6743-751X)
- Julia H. Goedecke (ORCID: https://orcid.org/0000-0001-6795-4771)
- Mamosilo Lichaba
Institutions
- National Health Laboratory Service (ZA)
- South African Medical Research Council (ZA)
- University of Cape Town (ZA)
- University of the Witwatersrand (ZA)
- Stellenbosch University (ZA)
- Churchill Hospital (GB)
- Health Net (US)
- University of Manchester (GB)
- National Institute for Health and Care Research (GB)
- University of Oxford (GB)
- St Mary's Hospital (GB)
- Oxford Biomedical Research (US)
- Vall d'Hebron Institut de Recerca (ES)
- Oxford Centre for Diabetes, Endocrinology and Metabolism (GB)
- International Federation of Sports Medicine (CH)
- University of Southampton (GB)
- Umeå University (SE)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1210/clinem/dgaf256
- Primary Topic
- HIV-related health complications and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00