SHBG, Testosterone, and Type 2 Diabetes Risk in Middle-Aged African Women: Exploring the Effect of HIV and Menopause

We show for the first time that midlife African WH have higher SHBG and lower total and free testosterone than WOH, which corresponded to their higher β-cell function, suggesting a putative protective effect of SHBG on T2D risk in WH.

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Publication Details

Journal
The Journal of Clinical Endocrinology & Metabolism
Published
2025-04-26
DOI
https://doi.org/10.1210/clinem/dgaf256
Primary Topic
HIV-related health complications and treatments
Type
article
Field-Weighted Citation Impact
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article

SHBG, Testosterone, and Type 2 Diabetes Risk in Middle-Aged African Women: Exploring the Effect of HIV and Menopause

Lisa K. Micklesfield, André Pascal Kengne, Karl‐Heinz Storbeck, Hylton Gibson et al.
The Journal of Clinical Endocrinology & Metabolism
HIV-related health complications and treatments
article

SHBG, Testosterone, and Type 2 Diabetes Risk in Middle-Aged African Women: Exploring the Effect of HIV and Menopause

Lisa K. Micklesfield, André Pascal Kengne, Karl‐Heinz Storbeck, Hylton Gibson, David M. Selva, Maphoko Masemola, Fredrik Karpe, James Hawley, Amy E. Mendham, Tommy Olsson, Nigel J. Crowther, Clément Kufe, Shane Anthony Norris, Itai M. Magodoro, Ikanyeng D Seipone, Tinashe Chikowore, Julia H. Goedecke, Mamosilo Lichaba
article en

Abstract

We show for the first time that midlife African WH have higher SHBG and lower total and free testosterone than WOH, which corresponded to their higher β-cell function, suggesting a putative protective effect of SHBG on T2D risk in WH.

The Journal of Clinical Endocrinology & MetabolismVol. 110(12)
National Health Laboratory Service (ZA), South African Medical Research Council (ZA), University of Cape Town (ZA), University of the Witwatersrand (ZA), Stellenbosch University (ZA), Churchill Hospital (GB), Health Net (US), University of Manchester (GB), National Institute for Health and Care Research (GB), University of Oxford (GB), St Mary's Hospital (GB), Oxford Biomedical Research (US), Vall d'Hebron Institut de Recerca (ES), Oxford Centre for Diabetes, Endocrinology and Metabolism (GB), International Federation of Sports Medicine (CH), University of Southampton (GB), Umeå University (SE)
Good health and well-being
Openalex Percentile: Top 85%
HIV-related health complications and treatments
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