Zapotin mitigates breast cancer progression by targeting PKCε mediated glycolytic pathway regulation
This study demonstrated the role of PKCε mediated HIF-1ɑ, VEGF, and glycolytic pathways in promoting breast carcinogenicity and demonstrated Zapotin as a potential treatment option for different types of breast tumors.
Authors
- Yasmin Badshah
- Khushbukhat Khan (ORCID: https://orcid.org/0000-0002-9946-9057)
- Janeen H. Trembley (ORCID: https://orcid.org/0000-0003-3597-2611)
- Naeem Mahmood Ashraf (ORCID: https://orcid.org/0000-0003-3614-0702)
- Arslan Hamid (ORCID: https://orcid.org/0000-0002-2861-013X)
- Fohad Mabood Husain (ORCID: https://orcid.org/0000-0001-6598-4328)
- Suhail Razak (ORCID: https://orcid.org/0000-0003-2167-8630)
- Maria Shabbir (ORCID: https://orcid.org/0000-0002-5685-3059)
- Maryam Anwar (ORCID: https://orcid.org/0000-0002-0545-8403)
- Dilawar Khan
- Tayyaba Afsar (ORCID: https://orcid.org/0000-0003-3181-5731)
Institutions
- University of Minnesota (US)
- University of Bonn (DE)
- King Saud University (SA)
- Minneapolis VA Health Care System (US)
- University of Minnesota Medical Center (US)
- National University of Sciences and Technology (PK)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-04-28
- DOI
- https://doi.org/10.1186/s12885-025-14202-z
- Citations
- 1
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- King Saud University