Integrating proteomics and network pharmacology to explore the relevant mechanism of Huangkui capsule in the treatment of chronic glomerulonephritis
HKC exerts renoprotective effects in CGN by regulating multiple signaling pathways, notably HIF-1, VEGF, PI3K-Akt, MAPK, and PPAR. Through attenuation of inflammatory and oxidative responses, HKC alleviates renal pathological damage and supports kidney function, offering mechanistic insight into its multi-target therapeutic potential.
Authors
- Hong Ge (ORCID: https://orcid.org/0000-0002-2958-3866)
- Fu Wang (ORCID: https://orcid.org/0000-0001-9222-0833)
- Chang Wen
- Jia Zou (ORCID: https://orcid.org/0000-0001-5617-7161)
- Jia Li (ORCID: https://orcid.org/0000-0003-3224-001X)
Institutions
- China Pharmaceutical University (CN)
- Lianyungang Runzhong Pharmaceutical (China) (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fphar.2025.1560420
- Citations
- 3
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.39