Bleeding control in severe spinal deformity correction surgery: the use of tranexamic acid combined with desmopressin

To investigate the efficacy of tranexamic acid combined with desmopressin in reducing intraoperative and postoperative bleeding during severe spinal deformity correction surgery. Around 30 cases of orthopedic surgery for severe spinal deformity were included in this study. They were divided into study group and control group. The surgical duration, intraoperative blood loss, postoperative 24-h drainage volume, hemoglobin levels, and coagulation function indicators at 24 h postoperatively were recorded and compared between the two groups. The intraoperative blood loss and 24-h postoperative drainage volume of the study group were significantly lower than those of the control group (<i>P</i> < 0.05). The decrease in hemoglobin levels was less pronounced in the study group, and the coagulation function indicators remained more stable within 24 h postoperatively. Compared with the control group, both <i>P</i> < 0.05. The combination of tranexamic acid and desmopressin effectively reduces intraoperative and postoperative bleeding in severe spinal deformity correction surgery, and demonstrates a favorable safety profile.