Efficacy of naloxone in reducing hypoxemia and duration of immobility following focal to bilateral tonic–clonic seizures
Release of endogenous opioids might participate in the severity of post-ictal hypoxemia and immobility after focal to bilateral tonic-clonic seizures (FBTCS). We conducted a multicenter double-blind randomized placebo-controlled trial evaluating the efficacy of an opioid antagonist, naloxone (NLX), administered within 2 min following the end of FBTCS. The efficacy of NLX was further explored with a comparison with historical control. NLX did not improve the delay of recovery or the severity of post-ictal hypoxemia. Post-ictal immobility was significantly shorter in the NLX group when compared to historical control. The impact of these results on SUDEP prevention will require additional studies.
Authors
- Sylvain Rheims (ORCID: https://orcid.org/0000-0002-4663-8515)
- Philippe Ryvlin (ORCID: https://orcid.org/0000-0001-7775-6576)
- Jérôme Petit (ORCID: https://orcid.org/0000-0002-8622-1087)
- Anca Nica (ORCID: https://orcid.org/0000-0002-6839-825X)
- Arielle Crespel (ORCID: https://orcid.org/0000-0002-2203-1938)
- Laure Mazzola (ORCID: https://orcid.org/0000-0001-7307-0809)
- Pascal Roy (ORCID: https://orcid.org/0000-0003-3837-3198)
- Julien Biberon (ORCID: https://orcid.org/0000-0003-4349-4007)
- Véronique Michel (ORCID: https://orcid.org/0000-0002-8900-7190)
- Martine Lemesle Martin
- Philippe Derambure
- Luc Valton (ORCID: https://orcid.org/0000-0001-6718-8210)
- Mathilde Leclercq (ORCID: https://orcid.org/0000-0001-6262-1740)
- Laurent Bezin (ORCID: https://orcid.org/0000-0001-6411-4267)
- Vincent Navarro (ORCID: https://orcid.org/0000-0003-0077-8114)
- Sébastien Boulogne (ORCID: https://orcid.org/0000-0001-8681-7369)
- Édouard Hirsch (ORCID: https://orcid.org/0000-0003-0833-8850)
- Fabrice Bartoloméi (ORCID: https://orcid.org/0000-0002-1678-0297)
- Fatima Chorfa
- Louis Maillard (ORCID: https://orcid.org/0000-0003-2895-0385)
- Catherine Mercier
- Vincent Rossero
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Université de Tours (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Université de Lille (FR)
- Centre Hospitalier Universitaire Vaudois (CH)
- Sorbonne Université (FR)
- Centre de Recherche en Neurosciences de Lyon (FR)
- Centre Hospitalier Universitaire de Tours (FR)
- Centre Hospitalier Régional et Universitaire de Nancy (FR)
- Hospices Civils de Lyon (FR)
- Hôpital Pellegrin (FR)
- Pitié-Salpêtrière Hospital (FR)
- Centre Médical de La Teppe (FR)
- Maison des Sciences sociales et des Humanités de Dijon (FR)
- Centre de recherche cerveau et cognition (FR)
- Institut du Cerveau (FR)
- Centre Hospitalier Universitaire de Rennes (FR)
- Centre Hospitalier Universitaire de Saint-Étienne (FR)
- Hôpital de la Timone (FR)
- Université de Strasbourg (FR)
Publication Details
- Journal
- Epilepsia Open
- Published
- 2025-04-28
- DOI
- https://doi.org/10.1002/epi4.70046
- Citations
- 3
- Primary Topic
- Neuroscience of respiration and sleep
- Type
- article
- Field-Weighted Citation Impact
- 2.74
Funders
- Agence Nationale de la Recherche