Increased HSD11β1 Expression in Human Leiomyomatous Uteri: Implication for Enhanced Glucocorticoid Signaling
FKBP51 not only inhibits but can augment GR-mediated transcription. Importantly, FKBP51-GR interactions increase HSD11B1 levels in leiomyoma cells, generating a pathological FKBP51-GR-HSD11β1 circle, altering transcription of downstream extracellular matrix and smooth muscle genes to induce a myofibroblast phenotype, thereby possibly contributing to leiomyoma pathogenesis.
Authors
- Emad Mikhail (ORCID: https://orcid.org/0000-0003-1502-3654)
- Charles J. Lockwood (ORCID: https://orcid.org/0000-0002-7765-4999)
- Carrie A. Malcom
- Busra Cetinkaya-Un (ORCID: https://orcid.org/0000-0001-9466-4278)
- Anthony N. Imudia (ORCID: https://orcid.org/0000-0002-5932-737X)
- Ozlem Guzeloglu‐Kayisli (ORCID: https://orcid.org/0000-0001-5448-917X)
- Burak Ün (ORCID: https://orcid.org/0000-0002-8885-7062)
- Umit A. Kayisli (ORCID: https://orcid.org/0000-0002-0379-2168)
- Erika P. New (ORCID: https://orcid.org/0000-0002-5935-5223)
- Xiaofang Guo
Institutions
- University of South Florida (US)
- Shady Grove Fertility Center (US)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-04-27
- DOI
- https://doi.org/10.1210/clinem/dgaf255
- Citations
- 1
- Primary Topic
- Uterine Myomas and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.06
Funders
- University of South Florida