Sex differences in cerebrospinal fluid proteomics of patients with restless legs syndrome
This study identified a cerebrospinal fluid proteomic signature in RLS, implicating immune and inflammatory pathways in the disease's pathophysiology. Significant sex differences in protein level suggest potential sex-specific mechanisms in RLS, warranting further investigation. These findings contribute to the current understanding of RLS and could inform future therapeutic strategies.
Authors
- Giuseppe Lanza (ORCID: https://orcid.org/0000-0002-5659-662X)
- Raffaele Ferri (ORCID: https://orcid.org/0000-0001-6937-3065)
- Maria P. Mogavero (ORCID: https://orcid.org/0000-0001-6662-2281)
- Brian B. Koo (ORCID: https://orcid.org/0000-0003-0166-5074)
- Giovanna Marchese (ORCID: https://orcid.org/0000-0002-9594-0729)
- Gang Peng (ORCID: https://orcid.org/0000-0003-0307-9351)
- Luigi Ferini‐Strambi (ORCID: https://orcid.org/0000-0003-2867-5424)
Institutions
- Vita-Salute San Raffaele University (IT)
- San Raffaele University of Rome (IT)
- Yale University (US)
- University of Catania (IT)
- VA Connecticut Healthcare System (US)
- Oasi Maria SS (IT)
- Surgical Specialties (Canada) (CA)
- Mylan (South Africa) (ZA)
- Genomix Biotech (India) (IN)
- Center for Genomic Science (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- SLEEP
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1093/sleep/zsaf112
- Citations
- 2
- Primary Topic
- Restless Legs Syndrome Research
- Type
- article
- Field-Weighted Citation Impact
- 2.71