Precision Monitoring of Immunosuppressive Agent Concentrations in Cardiac Tissue of Pediatric Heart Transplant Recipients
Myocardial TAC, MPA, and MPAG concentrations are associated with blood levels, whereas those of EVR showed no significant correlation. Further, the tissue perfusion efficiencies of TAC and EVR decreased with age. This study highlights the value of LC-MS/MS for immunosuppressant monitoring after pediatric heart transplantation.
Authors
- Atsuko Ueyama
- Hidekazu Ishida (ORCID: https://orcid.org/0000-0001-7284-8914)
- Jun Narita
- Hisao Nishino
- Natsuka Kimura
- Chika Yoshihara (ORCID: https://orcid.org/0009-0006-0129-1956)
- Yasuji Kitabatake (ORCID: https://orcid.org/0000-0002-2907-9512)
- Kazuhisa Hashimoto (ORCID: https://orcid.org/0009-0002-0797-8506)
- Kenichi Aizawa (ORCID: https://orcid.org/0000-0002-5996-0490)
- Ryo Ishii (ORCID: https://orcid.org/0000-0002-0267-0652)
- Masaki Hirose (ORCID: https://orcid.org/0000-0002-3523-9420)
- Ken Hayashi (ORCID: https://orcid.org/0009-0008-7361-603X)
- Kazutoshi Ueda
- Ryozo Nagai
Institutions
- Jichi Medical University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Pediatric Transplantation
- Published
- 2025-04-28
- DOI
- https://doi.org/10.1111/petr.70092
- Primary Topic
- Transplantation: Methods and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science