Suppression of the Prostaglandin I2–Type 1 Interferon Axis Induces Extramedullary Hematopoiesis to Promote Cardiac Repair After Myocardial Infarction
Together, our findings revealed that a PGI2-IFN axis was involved in spleen EMH after MI, providing new mechanistic insights into spleen EMH after MI and offering a new therapeutic target for treating ischemic cardiac injury.
Authors
- Zhenqiu Liu (ORCID: https://orcid.org/0000-0002-5244-6894)
- Xuelian Shi
- Hui Cheng (ORCID: https://orcid.org/0000-0002-1988-6572)
- Huizhen Lv (ORCID: https://orcid.org/0000-0003-2554-4293)
- Fanglin Gou (ORCID: https://orcid.org/0000-0002-8390-9548)
- Meixi Quan
- Tao Cheng (ORCID: https://orcid.org/0000-0002-5925-2769)
- Ding Ai (ORCID: https://orcid.org/0000-0001-5992-9904)
- Ping Zhu (ORCID: https://orcid.org/0000-0002-4521-7524)
- Kan Li (ORCID: https://orcid.org/0000-0002-5762-7440)
- Chenchen Wang (ORCID: https://orcid.org/0009-0004-2630-4149)
- Ying Yu (ORCID: https://orcid.org/0000-0002-6476-1752)
- Qian Liu (ORCID: https://orcid.org/0000-0002-2788-6222)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Institute for Stem Cell Biology and Regenerative Medicine (IN)
- Peking University First Hospital (CN)
- Institute of Hematology & Blood Diseases Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Circulation
- Published
- 2025-04-28
- DOI
- https://doi.org/10.1161/circulationaha.124.069420
- Citations
- 9
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 7.18