Brucella inactivated vaccine elicits immunity against B. melitensis infection in mice and guinea pigs
In summary, CF significantly induces both humoral and cellular immunity in mice. This study reports for the first time that a safe and effective inactivated Brucella vaccine (CF) can induce cellular immune responses and effectively prevent animal brucellosis.
Authors
- Chuangfu Chen (ORCID: https://orcid.org/0000-0001-5181-6518)
- Ruirui Hu (ORCID: https://orcid.org/0000-0002-0178-5941)
- Yimei Xu (ORCID: https://orcid.org/0000-0003-0013-4044)
- Wenhao Ren (ORCID: https://orcid.org/0000-0002-4167-2933)
- Mengxin Yao
- Zhongchen Ma (ORCID: https://orcid.org/0000-0002-3951-4610)
- Qianyi Zhang (ORCID: https://orcid.org/0000-0001-8509-7136)
- Yong Wang (ORCID: https://orcid.org/0000-0003-0587-3516)
- Wenjia Wang (ORCID: https://orcid.org/0000-0002-2892-6214)
- Hui Zhang (ORCID: https://orcid.org/0009-0002-3578-5664)
- Jinliang Sheng (ORCID: https://orcid.org/0000-0001-6887-5581)
Institutions
- Shihezi University (CN)
- Xinjiang Uygur Autonomous Region Disease Prevention and Control Center (CN)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1016/j.biopha.2025.118077
- Citations
- 4
- Primary Topic
- Brucella: diagnosis, epidemiology, treatment
- Type
- article
- Field-Weighted Citation Impact
- 9.42