Paired Deep Brain Stimuli Elicit Short‐Term Facilitation in Globus Pallidus Interna and Subthalamic Nucleus
Single and paired DBS pulses elicit local oscillations with larger amplitudes in the STN than in the GPi. Otherwise, the responses display similar time dynamics and short-term neuroplasticity. These findings could inform therapeutic innovation with future DBS systems that utilize sensing technologies. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Cameron Gordon
- Christopher L. Gonzalez (ORCID: https://orcid.org/0000-0001-8816-4445)
- Sarah A. Brinkerhoff (ORCID: https://orcid.org/0000-0002-1030-5233)
- Anthony Varghese (ORCID: https://orcid.org/0000-0002-2923-6389)
- J. Nicole Bentley (ORCID: https://orcid.org/0000-0002-8303-071X)
- Arie Nakhmani (ORCID: https://orcid.org/0000-0002-0987-4834)
- Marshall T. Holland (ORCID: https://orcid.org/0000-0002-4936-4193)
- Harrison C. Walker (ORCID: https://orcid.org/0000-0002-4601-3486)
Institutions
- Jackson Memorial Hospital (US)
- University of Mississippi Medical Center (US)
- University of Alabama at Birmingham (US)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-04-28
- DOI
- https://doi.org/10.1002/mds.30203
- Citations
- 3
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- National Institute of Neurological Disorders and Stroke