A novel electrochemical dopamine biosensor based on nano-MnO <sub>2</sub>-functionalized red blood cells for health monitoring
Quantitative analysis of dopamine (DA) in body fluids is essential owing to its close relation to some nervous system diseases. However, there are still significant challenges in exploring new materials with good sensitivity and biocompatibility for real-time medical monitoring. Herein, we developed the nano-MnO<sub>2</sub>-modified red blood cell (RBC@MnO<sub>2</sub>), a novel whole-cell electrochemical biosensor for detecting DA. The n-MnO<sub>2</sub> grown in situ on the cell surface can increase the transmembrane electron transfer rate and electrochemically active surface area of the catalyst. The as-prepared biosensor exhibits a high sensitivity (11.73 μA μM<sup>−1</sup>cm<sup>−2</sup>), a low detection limit (0.068 μM), and a wide linear range (0.6-160 μM) toward DA detection, which can be applied for DA detection in real-time health monitoring in whole blood samples with satisfactory results.
Authors
- Lin Yang (ORCID: https://orcid.org/0000-0002-0954-6240)
- Xiangli Ru
- Ke Guo (ORCID: https://orcid.org/0000-0003-1809-3172)
- Xiaoming Ma (ORCID: https://orcid.org/0000-0002-3209-4182)
- Lu Wei (ORCID: https://orcid.org/0000-0003-1136-6916)
- Yuming Guo (ORCID: https://orcid.org/0000-0002-1766-6592)
- Lingxue Tang (ORCID: https://orcid.org/0000-0002-2234-9786)
- Jingyu He
Publication Details
- Journal
- Nano Research
- Published
- 2025-04-28
- DOI
- https://doi.org/10.26599/nr.2025.94907508
- Citations
- 3
- Primary Topic
- Electrochemical sensors and biosensors
- Type
- article
- Field-Weighted Citation Impact
- 2.19
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Henan Province
- Higher Education Discipline Innovation Project