PPAR-mediated reduction of lipid accumulation in hepatocytes involves the autophagy-lysosome-mitochondrion axis
All PPAR agonists were able to promote the clearance of lipids in cells loaded with long-chain fatty acids. The key role of acid hydrolysis to generate fatty acids, which can be then catabolized in the mitochondria, and the ability of the PPAR system to sustain each phase of this clearing process were elucidated.
Authors
- Giuseppe Danilo Norata (ORCID: https://orcid.org/0000-0002-6081-1257)
- Lorenzo Da Dalt (ORCID: https://orcid.org/0000-0002-6298-8689)
- Alice Ossoli (ORCID: https://orcid.org/0000-0002-9902-252X)
- Federica Cetti
- C Garavaglia
- Monica Gomaraschi (ORCID: https://orcid.org/0000-0003-3082-2120)
Institutions
- University of Milan (IT)
- Pharmac (NZ)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-04-28
- DOI
- https://doi.org/10.1080/07853890.2025.2497112
- Citations
- 10
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 13.54
Funders
- Università degli Studi di Milano
- European Atherosclerosis Society
- European Commission
- Ministero della Salute
- Ministero dell'Università e della Ricerca