Effect of Fangxia-Dihuang Decoction on doxorubicin-induced cognitive impairment in breast cancer animal model
In the animal model, FXDH has the effect of anti-cognitive impairment after chemotherapy for breast cancer, and can improve the DOX induced learning, memory and cognitive impairment in mice. FXDH can reverse DOX induced neuroinflammation by improving the neurodegenerative changes caused by DOX, reducing pro-inflammatory cytokine levels in mouse serum and hippocampus, increasing anti-inflammatory cytokine levels, and reducing oxidative stress response.
Authors
- Xiaohua Pei (ORCID: https://orcid.org/0000-0003-3043-8874)
- N. Chen
- Xuan Wang (ORCID: https://orcid.org/0000-0002-0011-5663)
- Jiànróng Lǐ (ORCID: https://orcid.org/0000-0002-7130-1084)
- Qiqi Sun
- Baoyong Lai (ORCID: https://orcid.org/0000-0002-9464-6245)
Institutions
- Beijing University of Chinese Medicine (CN)
- Capital Medical University (CN)
- Xiamen University (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Beijing Obstetrics and Gynecology Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fonc.2025.1515498
- Citations
- 2
- Primary Topic
- Cancer-related cognitive impairment studies
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Natural Science Foundation of China