Ex vivo quantification of intracellular pH in Drosophila Malpighian tubule reveals basolateral HCO3−/oxalate exchange through a novel oxalate transporter “Neat”
These data indicate Neat is a significant <i>Drosophila</i> basolateral MT oxalate transporter and the basolateral movement of oxalate is functionally coupled to movement of acid equivalents, potentially as Ox<sup>2-</sup>/HCO<sub>3</sub> <sup>-</sup> exchange, Ox<sup>2-</sup>/OH<sup>-</sup> exchange, or Ox<sup>2-</sup>:H<sup>+</sup> co-transport.
Authors
- James W Decker
- Michael F. Romero (ORCID: https://orcid.org/0000-0002-1555-7835)
- Heather L. Holmes
- David B. Mount (ORCID: https://orcid.org/0000-0003-0310-2304)
- Adam J. Rossano (ORCID: https://orcid.org/0000-0001-8959-106X)
- Jacob B. Anderson (ORCID: https://orcid.org/0000-0003-1343-3908)
- Lili Zhang (ORCID: https://orcid.org/0000-0002-1667-4611)
- Asim K. Mandal
Institutions
- Boston University (US)
- Brigham and Women's Hospital (US)
- Mayo Clinic (US)
- Roxbury Community College (US)
- Mayo Clinic in Arizona (US)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fphys.2025.1468451
- Primary Topic
- Photosynthetic Processes and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health