Uncovering the connection between tunicamycin-induced respiratory deficiency and reduced fluconazole tolerance in Candida glabrata
These results underscore the pivotal role of TUN-induced ER stress in modulating FLC tolerance via respiratory deficiency and alterations in ergosterol metabolism. Our study emphasizes the importance of mitochondrial integrity in maintaining drug tolerance in <i>C. glabrata</i> and suggests potential therapeutic strategies targeting metabolic pathways associated with antifungal tolerance. A deeper understanding of these mechanisms may enhance our capacity to effectively combat fungal infections.
Authors
- Maoji Zhang
- Liangsheng Guo (ORCID: https://orcid.org/0000-0002-1596-0851)
- Yi Xu (ORCID: https://orcid.org/0000-0001-8971-9334)
- Yubo Dong (ORCID: https://orcid.org/0009-0003-3272-1363)
- Jing Wang (ORCID: https://orcid.org/0000-0001-9496-6276)
- Lijun Zheng (ORCID: https://orcid.org/0000-0002-3283-3619)
- Lei Ma (ORCID: https://orcid.org/0000-0003-2083-8372)
Institutions
- Soochow University (CN)
- 82th Hospital of Pla (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Jinzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fmicb.2025.1528341
- Citations
- 1
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province