Mechanical property changes of glial LC and RGC axons in response to high intraocular pressure
The progressive decrease in Young's modulus indicated that prolonged high IOP compromises the structural integrity and mechanical properties of the LC and RGC axons. This mechanical weakening likely contributes to the pathophysiological process of optic nerve injury in glaucoma. The present study offers important insights into the biomechanical mechanisms underlying glaucomatous damage, which may guide future research and therapeutic strategies.
Authors
- Jifeng Ren (ORCID: https://orcid.org/0000-0002-4315-2595)
- Xiuqing Qian (ORCID: https://orcid.org/0000-0003-4267-8728)
- Bochao Ma
- Yushu Liu (ORCID: https://orcid.org/0000-0001-6172-4094)
- Liu Liu (ORCID: https://orcid.org/0000-0003-2671-5293)
Institutions
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- Capital Medical University (CN)
- Peking University (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fbioe.2025.1574231
- Citations
- 1
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- National Natural Science Foundation of China