A preliminary randomized trial of the safety, tolerability, and clinical effects of hemp-derived cannabidiol in alcohol use disorder
In this pilot study, safety profiles fsCBD and bsCBD were similar, and fsCBD was associated with a greater reduction in craving and AUD symptoms relative to both bsCBD and placebo. Future studies with larger sample sizes will be necessary to replicate and extend these findings by addressing the question of whether a small amount of THC may work synergistically with CBD.
Authors
- Aviva K. Olsavsky (ORCID: https://orcid.org/0000-0002-7779-1491)
- Kent E. Hutchison (ORCID: https://orcid.org/0000-0002-4805-9277)
- Angela D. Bryan (ORCID: https://orcid.org/0000-0002-6019-3380)
- Jarrod M. Ellingson (ORCID: https://orcid.org/0000-0001-9932-2656)
- L. Cinnamon Bidwell (ORCID: https://orcid.org/0000-0001-6762-7586)
- Raeghan L. Mueller (ORCID: https://orcid.org/0000-0001-5249-1532)
- Rachael Rzasa-Lynn
- Judith Hooper (ORCID: https://orcid.org/0009-0002-1350-3881)
Institutions
- University of Colorado Boulder (US)
- Children's Hospital Colorado (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fpsyt.2025.1516351
- Citations
- 3
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- American Academy of Child and Adolescent Psychiatry
- National Institute on Alcohol Abuse and Alcoholism
- National Institute on Drug Abuse