The effects of ondansetron on diabetes and high-fat diet-induced liver disease: a critical role for protein tyrosine phosphatase 1B
These therapeutic effects position ondansetron as a promising candidate for further investigation in clinical settings for the treatment of diabetes and NAFLD and, hence, support the use of the drug repurposing approach for addressing the growing burden of metabolic diseases.
Authors
- Maryam Aqeel
- Muhammad Zahid (ORCID: https://orcid.org/0000-0002-7222-6776)
- Mustafeez Mujtaba Babar (ORCID: https://orcid.org/0000-0001-9005-8991)
- Fawad Naeem
- Abdelali Agouni (ORCID: https://orcid.org/0000-0002-8363-1582)
- Fawad Ali Shah
- Sohaib Zafar Malik (ORCID: https://orcid.org/0000-0002-3454-4802)
Institutions
- Prince Sattam Bin Abdulaziz University (SA)
- Shifa Tameer-e-Millat University (PK)
- Riphah International University (PK)
- Qatar University (QA)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fphar.2025.1565628
- Citations
- 1
- Primary Topic
- Protein Tyrosine Phosphatases
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Fonds National de la Recherche Luxembourg
- Qatar University
- Qatar National Research Fund