Selective inhibition of canonical STAT3 signaling suppresses K-ras mutant lung tumorigenesis and reinvigorates anti-tumor immunity
Our results highlight the importance of STAT3 in driving early tumorigenesis and offer a preventative treatment window for high-risk individuals and patients with early-stage KM-LUAD.
Authors
- Seyed Javad Moghaddam (ORCID: https://orcid.org/0000-0002-5350-307X)
- Nastaran Karimi (ORCID: https://orcid.org/0000-0002-9827-6974)
- Shanshan Deng (ORCID: https://orcid.org/0000-0002-2166-5082)
- Marco Ramos-Castañeda
- Moses M. Kasembeli
- Stephen Peng
- Zahraa Rahal (ORCID: https://orcid.org/0000-0002-3595-7027)
- Humam Kadara (ORCID: https://orcid.org/0000-0003-2976-9115)
- Cody Chou
- Walter V. Velasco (ORCID: https://orcid.org/0000-0001-9101-5758)
- Edwin J. Ostrin (ORCID: https://orcid.org/0000-0002-4538-6539)
- Sühendan Ekmekçioglu (ORCID: https://orcid.org/0000-0003-4079-6632)
- Sung-Nam Cho (ORCID: https://orcid.org/0000-0002-1115-8247)
- Michael J. Clowers (ORCID: https://orcid.org/0000-0002-5259-3464)
- Leticia G Hamana Zorrilla
- T. Kris Eckols
- David J. Tweardy (ORCID: https://orcid.org/0000-0001-8492-8460)
- Luisa M. Solis Soto (ORCID: https://orcid.org/0000-0002-1253-630X)
- Sayan Alekseev
- Maria T. Grimaldo (ORCID: https://orcid.org/0000-0002-2918-0231)
- Melody Zarghooni (ORCID: https://orcid.org/0000-0002-3765-3086)
- Bo Yuan (ORCID: https://orcid.org/0000-0001-8565-5994)
- Samuel Liu
- Avantika Krishna
- Annamarie L. Thompson
- Carlos Ignacio Rodriguez Reyna
- Katherine E. Larsen
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1575181
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancer Prevention and Research Institute of Texas
- National Institutes of Health
- National Cancer Institute