Selective inhibition of canonical STAT3 signaling suppresses K-ras mutant lung tumorigenesis and reinvigorates anti-tumor immunity

Our results highlight the importance of STAT3 in driving early tumorigenesis and offer a preventative treatment window for high-risk individuals and patients with early-stage KM-LUAD.

Authors

Institutions

Publication Details

Journal
Frontiers in Immunology
Published
2025-04-28
DOI
https://doi.org/10.3389/fimmu.2025.1575181
Primary Topic
Cytokine Signaling Pathways and Interactions
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Selective inhibition of canonical STAT3 signaling suppresses K-ras mutant lung tumorigenesis and reinvigorates anti-tumor immunity

Seyed Javad Moghaddam, Nastaran Karimi, Shanshan Deng, Marco Ramos-Castañeda et al.
Frontiers in Immunology
Cytokine Signaling Pathways and Interactions
article

Selective inhibition of canonical STAT3 signaling suppresses K-ras mutant lung tumorigenesis and reinvigorates anti-tumor immunity

Seyed Javad Moghaddam, Nastaran Karimi, Shanshan Deng, Marco Ramos-Castañeda, Moses M. Kasembeli, Stephen Peng, Zahraa Rahal, Humam Kadara, Cody Chou, Walter V. Velasco, Edwin J. Ostrin, Sühendan Ekmekçioglu, Sung-Nam Cho, Michael J. Clowers, Leticia G Hamana Zorrilla, T. Kris Eckols, David J. Tweardy, Luisa M. Solis Soto, Sayan Alekseev, Maria T. Grimaldo, Melody Zarghooni, Bo Yuan, Samuel Liu, Avantika Krishna, Annamarie L. Thompson, Carlos Ignacio Rodriguez Reyna, Katherine E. Larsen
article en

Abstract

Our results highlight the importance of STAT3 in driving early tumorigenesis and offer a preventative treatment window for high-risk individuals and patients with early-stage KM-LUAD.

Frontiers in ImmunologyVol. 16
The University of Texas MD Anderson Cancer Center (US), The University of Texas Health Science Center at Houston (US)
Cancer Prevention and Research Institute of Texas, National Institutes of Health, National Cancer Institute
Openalex Percentile: Top 87%
Cytokine Signaling Pathways and Interactions
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.