Anti-inflammatory effect and mechanism of stytontriterpene D on RAW264.7 cells and zebrafish
These results demonstrated that STD has an obvious anti-inflammatory effect, and its intrinsic molecular mechanism is possibly caused by inhibiting the NF-κB signaling pathway and regulating the phenotypic changes of M1 and M2 macrophages. Thus, STD may play a potential role in the treatment of inflammatory diseases.
Authors
- Chuqin Yu (ORCID: https://orcid.org/0000-0002-2021-014X)
- Qiuming Gao (ORCID: https://orcid.org/0000-0002-1232-4139)
- Lei Cai (ORCID: https://orcid.org/0000-0003-0935-1870)
- Xiangying Liu
- Zonghao Lin (ORCID: https://orcid.org/0000-0002-9452-589X)
- Feng Wang (ORCID: https://orcid.org/0000-0003-2771-5543)
- Q. F. Xie
Institutions
- Guangdong Pharmaceutical University (CN)
- Guangdong Laboratory Animals Monitoring Institute (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fphar.2025.1559022
- Citations
- 1
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.81