Exploring WNT pathway dysregulation in serrated colorectal cancer for improved diagnostic and therapeutic strategies
We developed a WNT-derived subtyping method to identify SCC from canonical CRC, which enhances the molecular understanding of this severe cancer subtype and provides potential therapeutic strategies. Our findings suggest that SCC patients may benefit from the HSP90 inhibitor NVP-AUY922, highlighting its potential as a targeted therapy.
Authors
- Yueliang Zhao (ORCID: https://orcid.org/0000-0003-4374-1602)
- Yin Tong (ORCID: https://orcid.org/0000-0001-6521-1915)
- Helen Hoi Ning Yan
- Fengzhi Zhu
Institutions
- Shanghai Jiao Tong University (CN)
- Queen Mary Hospital (CN)
- Hong Kong Science and Technology Parks Corporation (HK)
- Shanghai Ocean University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fgene.2025.1586867
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Shanghai Jiao Tong University