Single-cell transcriptomic construction of fibroblast score for analysis of immune infiltration in primary and metastatic ovarian cancer
In metastatic ovarian cancer, fibroblasts induce macrophage polarization through the TIMP3-regulated CXCL signaling pathway, which affects the prognosis of ovarian cancer patients and drug resistance of ovarian cancer cells.
Authors
- Qian Guo (ORCID: https://orcid.org/0000-0001-5199-6942)
- Hongmei Ding (ORCID: https://orcid.org/0000-0003-0805-8322)
- Qinlin Zheng (ORCID: https://orcid.org/0000-0001-7769-0810)
Institutions
- Affiliated Hospital of Southwest Medical University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fgene.2025.1549541
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00