Untargeted metabolic analysis in serum samples reveals metabolic signature in children with congenital heart failure on enalapril therapy
These are the first data to demonstrate a clear metabolic signature in children with CHD using ACEi. We identified metabolites whose concentrations were both associated with ACEi response and HF. This indicates more severe HF in patients with more profound treatment response. Our results will therefore allow further studies aiming at disentangling variability in ACEi treatment response.
Authors
- Nori J. L. Smeets (ORCID: https://orcid.org/0000-0002-4927-2459)
- Milica Bajčetić (ORCID: https://orcid.org/0000-0002-4564-5238)
- Ilja N. van Hoek
- Michiel Dalinghaus
- Stephanie Läer
- Saskia N. de Wildt (ORCID: https://orcid.org/0000-0002-0502-0647)
- Christoph Male (ORCID: https://orcid.org/0000-0002-4989-6421)
- Judith Jans (ORCID: https://orcid.org/0000-0003-0960-6263)
Institutions
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- University Medical Center Utrecht (NL)
- University of Belgrade (RS)
- Radboud Institute for Molecular Life Sciences (NL)
- Erasmus MC - Sophia Children’s Hospital (NL)
- University Children's Hospital, Belgrade (RS)
- Heinrich Heine University Düsseldorf (DE)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fped.2025.1530063
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00