Fluorescein-distribution in confocal laser endomicroscopy allows for discrimination between primary brain tumours and metastases
The concordant results from <i>in vitro</i>, <i>ex vivo</i> and <i>in vivo</i> investigations could show that the cellular accumulation of the staining agent SF varies depending on the tumour entity. While primary brain tumours rarely show intracellular SF accumulation, carcinoma metastases display SF intracellularly more frequently. Therefore, SF allows for a better discrimination between brain tumours and brain metastases when performing CLE <i>in vivo</i>.
Authors
- Johannes Reifenrath (ORCID: https://orcid.org/0000-0002-7216-5926)
- Bernhard Meyer (ORCID: https://orcid.org/0000-0001-6486-7955)
- M. Brielmaier
- Jürgen Schlegel (ORCID: https://orcid.org/0000-0002-5544-2717)
- Arthur Wagner (ORCID: https://orcid.org/0000-0001-9947-2240)
- Nicolas Pensel
- Jens Gempt (ORCID: https://orcid.org/0000-0003-4123-4690)
- Franziska Ganster
Institutions
- Universität Hamburg (DE)
- TUM Klinikum (DE)
- University Medical Center Hamburg-Eppendorf (DE)
Publication Details
- Journal
- Frontiers in Surgery
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fsurg.2025.1567711
- Citations
- 1
- Primary Topic
- MRI in cancer diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 1.36