Mitochondrial metabolism is rapidly re-activated in mature neutrophils to support stimulation-induced response
Together, these results demonstrate that mitochondrial metabolism is dynamically remodeled and plays a significant role in neutrophils. Furthermore, these findings point to the therapeutic potential of mitochondrial pyruvate carrier inhibitors in a range of conditions where dysregulated neutrophil response drives inflammation and contributes to pathology.
Authors
- Jing Fan (ORCID: https://orcid.org/0000-0002-5326-5358)
- Anna Huttenlocher A (ORCID: https://orcid.org/0000-0001-7940-6254)
- James A. Votava (ORCID: https://orcid.org/0000-0002-1452-4468)
- Frances M. Smith (ORCID: https://orcid.org/0000-0001-5479-4692)
- Jorgo Lika (ORCID: https://orcid.org/0000-0003-4563-7569)
- Rupsa Datta (ORCID: https://orcid.org/0000-0002-6432-2389)
- Melissa C. Skala (ORCID: https://orcid.org/0000-0002-6320-7637)
- Aleksandr Kralovec
- Carlos A. Mellado Fritz
Institutions
- University of Wisconsin–Madison (US)
- Morgridge Institute for Research (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1572927
- Citations
- 8
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 6.38
Funders
- National Institute of General Medical Sciences
- National Institute of Allergy and Infectious Diseases
- National Center for Advancing Translational Sciences