In vitro study: HIF-1α-dependent glycolysis enhances NETosis in hypoxic conditions
This study provides novel insights into the interplay between metabolic reprogramming and NETosis in response to hypoxic stress. We identify HIF-1α-dependent glycolysis as a key driver of NETs formation, advancing our understanding of the mechanisms underlying hypoxia-related inflammatory diseases. These findings also suggest that targeting metabolic pathways may offer potential therapeutic strategies for modulating immune responses in hypoxia-associated disorders.
Authors
- Yanjun Wang (ORCID: https://orcid.org/0009-0003-0714-7160)
- Juanli Liu (ORCID: https://orcid.org/0009-0003-2219-968X)
- Tana Wuren (ORCID: https://orcid.org/0000-0003-2695-4737)
- Qiying Xu (ORCID: https://orcid.org/0000-0002-2260-488X)
- Yi Ye (ORCID: https://orcid.org/0000-0003-3795-4767)
- Ziqi Yang
- Ri-Li Ge
Institutions
- Qinghai University (CN)
- Qinghai University Affiliated Hospital (CN)
- Qinghai Provincial Peoples Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1583587
- Citations
- 13
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 10.37
Funders
- National Natural Science Foundation of China
- National Science and Technology Major Project