Optimization of neuron-specific interfering peptides targeting GABAB receptor downregulation for proteolytic stability for conferring neuroprotection in a mouse model of cerebral ischemia
These findings confirm the potential of these peptides as neuroprotective agents and emphasize the importance of proteolytic stability of peptide drugs for their successful <i>in-vivo</i> application.
Authors
- Musadiq A. Bhat
- Thomas Grampp
- Dietmar Benke (ORCID: https://orcid.org/0000-0003-1846-4711)
- Mohammad Hleihil (ORCID: https://orcid.org/0000-0003-1787-5332)
Institutions
- University of Zurich (CH)
- ETH Zurich (CH)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fphar.2025.1576884
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung