Exercise training reduces cardiac fibrosis, promoting improvement in arrhythmias and cardiac dysfunction in an experimental model of chronic chagasic cardiomyopathy
Exercise reduced fibrosis in the heart and skeletal muscle, favoring the improvement of arrhythmias, and augment of cardiac complacency in mice with CCC, in addition to decreasing the expression of profibrotic and proinflammatory genes in the heart.
Authors
- Simone Garcia Macambira (ORCID: https://orcid.org/0000-0001-7960-6619)
- Milena Botelho Pereira Soares (ORCID: https://orcid.org/0000-0001-7549-2992)
- Alex Cleber Improta‐Caria (ORCID: https://orcid.org/0000-0002-8779-1188)
- Carine Machado Azevedo
- Juliana Fraga Vasconcelos (ORCID: https://orcid.org/0000-0003-4553-0315)
- Pâmela Santana Daltro
- Breno Cardim Barreto (ORCID: https://orcid.org/0000-0002-9897-2443)
- Gisele Batista Carvalho
- Carolina Kymie Vasques Nonaka (ORCID: https://orcid.org/0000-0002-1609-9469)
- Bruno Solano de Freitas Souza (ORCID: https://orcid.org/0000-0003-3771-0439)
Institutions
- Universidade Federal da Bahia (BR)
- Serviço Nacional de Aprendizagem Industrial (BR)
- D’Or Institute for Research and Education (BR)
- Hospital São Rafael (BR)
- Fundação Oswaldo Cruz (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fphys.2025.1558678
- Citations
- 2
- Primary Topic
- Trypanosoma species research and implications
- Type
- article
- Field-Weighted Citation Impact
- 2.71