Imrecoxib attenuates osteoarthritis by modulating synovial macrophage polarization through inactivating COX-2/PGE2 signaling pathway
This study unravels that Imrecoxib protects joint cartilage and attenuates osteoarthritis by modulating synovial macrophage polarization through inactivating COX-2/PGE2 signaling pathway, providing new drug delivery strategy for the clinical treatment of OA.
Authors
- Jingyuan Huang (ORCID: https://orcid.org/0000-0003-2273-9917)
- Jia‐Wei Shen (ORCID: https://orcid.org/0000-0002-4020-4062)
- Yuchen Liu (ORCID: https://orcid.org/0000-0002-2097-6348)
- Bin Zhang (ORCID: https://orcid.org/0000-0002-6631-7647)
- Peng Peng (ORCID: https://orcid.org/0009-0002-7993-8001)
- Jiangang Cao (ORCID: https://orcid.org/0009-0008-2528-5686)
- Wanling Zheng
Institutions
- Tianjin University of Sport (CN)
- Xuzhou Medical College (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- XinHua Hospital (CN)
- Tianjin Medical University General Hospital (CN)
- Tianjin Hospital (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fbioe.2025.1526092
- Citations
- 2
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 2.79