Structural and functional analysis of a homotrimeric collagen peptide
This study presents a chemically synthesized homotrimeric collagen peptide with superior purity, structural stability, and biological efficacy in promoting collagen synthesis. Compared to previous studies, this biomimetic material exhibits exceptional thermal stability (Tm = 326.15°C) and a well-balanced amino acid composition, enabling applications in cosmetics and medical devices requiring heat sterilization (e.g., autoclaving), as validated by our patented method (China Patent No. ZL202410309842.9).
Authors
- Hong‐Guang Xie (ORCID: https://orcid.org/0000-0002-1089-9457)
- Hongyi Zhao (ORCID: https://orcid.org/0000-0002-9548-7856)
- Takafumi Takebayashi
- Jin Song Dong (ORCID: https://orcid.org/0000-0002-6512-8326)
- Kexin Li (ORCID: https://orcid.org/0009-0001-7193-0534)
- Xingyun Long
- Nan Lu (ORCID: https://orcid.org/0009-0004-3169-9552)
- Yufan Li (ORCID: https://orcid.org/0000-0001-8191-2738)
- Boyu Zhou (ORCID: https://orcid.org/0000-0002-4125-7481)
- Xinling Zhang (ORCID: https://orcid.org/0000-0003-3783-0465)
- Xinyu Qin (ORCID: https://orcid.org/0009-0003-9554-6937)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Chengdu Medical College (CN)
- Beijing Hospital (CN)
- Peking University Third Hospital (CN)
- Shanghai Industrial Technology Institute (CN)
- Sichuan Academy Of Social Sciences (CN)
- The University of Tokyo (JP)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fbioe.2025.1575341
- Citations
- 2
- Primary Topic
- Collagen: Extraction and Characterization
- Type
- article
- Field-Weighted Citation Impact
- 1.19