Early emergence of motivational and hedonic feeding deficits in the TgF344-AD rat model of Alzheimer’s disease
Our findings highlight the TgF344-AD rat as a valuable model for studying early apathy-like behavior in AD and underscore the need to consider sex differences in AD research to better understand the prodromal phase of this disease.
Authors
- Alisa R. Kosheleff (ORCID: https://orcid.org/0000-0002-5738-7221)
- Nigel T. Maidment
- Irina Zhuravka
- Sean B. Ostlund (ORCID: https://orcid.org/0000-0003-1635-3911)
- Lindsay M. Lueptow (ORCID: https://orcid.org/0000-0001-5343-7618)
- Sally A. Frautschy (ORCID: https://orcid.org/0000-0003-0194-0363)
- Grace Chen (ORCID: https://orcid.org/0000-0003-1049-1571)
- Hoa A. Lam
Institutions
- University of California, Los Angeles (US)
- University of California, Irvine (US)
- Neurobehavioral Systems (US)
- VA Greater Los Angeles Healthcare System (US)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fnagi.2025.1572956
- Citations
- 4
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 4.66
Funders
- National Institutes of Health