Combined metabolome and transcriptome analysis revealed that MSTN regulated the process of bovine fatty acid metabolism in gut
Collectively, the result of this study indicated that MSTN gene mutation led to alterations in gut microbial metabolites by increasing the abundance of beneficial monounsaturated fatty acids (MUFAs) such as oleic acid, then to promote fatty acid degradation while inhibiting its synthesis by regulating the expression levels of relevant genes. These results provide a foundation for understanding the effects of MSTN gene mutations on gut metabolites and its certain functions that MSTN regulated via gut metabolites.
Authors
- Lei Yang (ORCID: https://orcid.org/0000-0002-9767-9026)
- Guangpeng Li (ORCID: https://orcid.org/0000-0001-8318-5853)
- Tong Wen (ORCID: https://orcid.org/0000-0003-0937-0086)
- Li Gao (ORCID: https://orcid.org/0000-0001-8762-6804)
- Lili Wang (ORCID: https://orcid.org/0000-0001-9347-3939)
- Hao Wu (ORCID: https://orcid.org/0000-0001-5738-4015)
- Yong Ma (ORCID: https://orcid.org/0000-0002-0425-8178)
- Ruobing Kang
Institutions
- Inner Mongolia University (CN)
- Baotou Teachers College (CN)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fvets.2025.1541257
- Citations
- 1
- Primary Topic
- Muscle metabolism and nutrition
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- Natural Science Foundation of Inner Mongolia