Impact of the variation in the number of white blood cells on the severity of sickle cell anemia in the hematology department of the Treichville University Hospital

Introduction: Sickle cell disease is a recurrent problem in the general population. Sickle cell disease is an inflammatory disease of which one of the markers is leukocytosis. The objective of the study was to describe the quantitative and qualitative aspects of the different forms of sickle cell disease correlated with leukocytosis in our study population. Methodology: Prospective cross-sectional descriptive study of people received at the Treichville University Hospital of the Hematology Department from July 1 to October 30, 2022. Results: We collected 40 cases among which a female predominance was noted with a sex ratio of 0.95. The 10<year-old age group was the most present (64.87%) with an average age of 26 years. Anemia was the most common haematological abnormality 94.60%, especially the microcytic hypochromic form. In addition, hyperleukocytosis was really a factor in the severity of homozygous sickle cell disease with regard to the proportion of sickle cell disease and leukocytes. Conclusion: being in apparent good health does not exclude the presence of a haematological abnormality. But the association of sickle cell anemia with leukocytosis increases the degree of severity. Keywords: Sickle cell anemia, Blood count, white blood cells.