Streptococcus mutans-derived extracellular vesicles promote skin wound healing via tRNA cargo
This study highlights the role of Sm EVs, particularly their tRNA variants, in promoting skin wound healing through a TLR3-dependent mechanism. These findings suggest that EVs from oral commensal bacteria may offer therapeutic potential for chronic, non-healing skin wounds.
Authors
- Kah Young Lee
- Dae‐Lyong Ha (ORCID: https://orcid.org/0000-0002-2268-4795)
- So‐Young Choi (ORCID: https://orcid.org/0000-0002-2563-3539)
- Tae‐Geon Kwon (ORCID: https://orcid.org/0000-0003-2799-0510)
- Heon‐Jin Lee (ORCID: https://orcid.org/0000-0002-1911-5014)
- Su‐Hyung Hong (ORCID: https://orcid.org/0000-0001-5569-3826)
- Tae-Lyn Kim
- Jin Wook Kim (ORCID: https://orcid.org/0000-0003-4157-9365)
- Dong‐Yeon Kim (ORCID: https://orcid.org/0000-0001-6169-4518)
- Su Young Oh
Institutions
- Kyungpook National University (KR)
- Kyungpook National University Medical Center (KR)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-04-28
- DOI
- https://doi.org/10.1186/s12951-025-03410-1
- Citations
- 8
- Primary Topic
- Streptococcal Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 15.03
Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Education, Science and Technology