Progranulin enhances M2 macrophage polarization and renal fibrosis by modulating autophagy in chronic kidney disease
PGRN plays a critical role in driving renal fibrosis by regulating macrophage polarization, autophagy, and mitochondrial dynamics. Our findings suggest that PGRN exacerbates CKD progression by promoting M2 macrophage polarization and disrupting autophagic processes, highlighting PGRN as a potential therapeutic target for the treatment of CKD and renal fibrosis.
Authors
- Yang Zhao
- Weichao Tu (ORCID: https://orcid.org/0000-0002-7276-4638)
- Shaoxiong Ming
- Dawei Wang (ORCID: https://orcid.org/0000-0001-8410-5237)
- Yi He (ORCID: https://orcid.org/0000-0003-0465-7352)
Institutions
- Second Military Medical University (CN)
- Ruijin Hospital (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Changhai Hospital (CN)
- Shuguang Hospital (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2025-04-28
- DOI
- https://doi.org/10.1007/s00018-025-05716-7
- Citations
- 8
- Primary Topic
- Dialysis and Renal Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 11.45
Funders
- National Natural Science Foundation of China